Technology:
SymClot

During normal hemostasis, platelets play several key roles in the wound healing process. Upon sensing an injury, platelets become activated, changing shape to a “sticky” stellate conformation and aggregating at bleeding sites. These “sticky” activated platelets bind to each other and to the coagulation protein fibrin, which is created via polymerization of the blood protein fibrinogen and is found exclusively at bleeding sites. The resultant platelet-fibrin mesh stems blood loss. Platelets additionally exert contractile forces on the bound fibrin, pulling the fibers closer together and causing overall retraction of the clot over time. This retraction allows blood to flow to reperfuse the healing tissues and enables subsequent stages of wound healing.