Platform:
Hemostatic Healing Hydrogels
SelSym Biotech's suite of Hemostatic Healing Hydrogels (H3) can be easily tuned to address a wide range of clinical needs in bleeding management and wound healing, including hemorrhage control, drug delivery, infection control, and long-term healing support for chronic wounds.
Surgical Bleeding
Safety profile enables use for management of severe surgical bleeding and proactive bleeding management in high risk patients undergoing procedures
Bleeding Disorders
Management of acute bleeding arising from bleeding disorders
Chronic Wound Care
Mechanically active topical wound care for difficult-to-treat and recurrent wounds (ex: diabetic ulcers)
Women's Health
Portable, shelf stable, postpartum hemorrhage control for underserved communities
Drug Delivery
Highly tunable hydrogel-based technology enables loading of compounds for targeted delivery of drugs, growth factors, and antimicrobial agents
Skin Barrier Repair
Skin barrier repair and topical bleeding management via highly absorbent hydrogel-based powders
Learn More
-
Nellenbach, K.; Mihalko, E.; Nandi, S.; Koch, D. W.; Shetty, J.; Moretti, L.; Sollinger, J.; Moiseiwitsch, N.; Sheridan, A.; Pandit, S.; et al. Ultrasoft platelet-like particles stop bleeding in rodent and porcine models of trauma. Sci. Transl. Med. (2024)
-
Nandi, S.; Mihalko, E.; Nellenbach, K.; Castaneda, M.; Schneible, J.; Harp, M.; Deal, H.; Daniele, M.; Menegatti, S.; Barker, T.H.; Brown, A.C. Synthetic Platelet Microgels Containing Fibrin Knob B Mimetic Motifs Enhance Clotting Responses. Advanced Therapeutics (2021).
-
Todd, J.; Bharadwaj, V.; Nellenbach, K.; Nandi, S.; Mihalko, E.; Copeland, C.; Brown, A.C.; Stabenfeldt, S. Platelet-Like Particles Reduce Coagulopathy-Related and Neuroinflammatory Pathologies Post-Experimental Traumatic Brain Injury. Journal of Biomedical Materials Research: Part B – Applied Biomaterials (2021).
-
Nandi, S.; Sommerville, L.; Nellenbach, K.; Mihalko, E.; Erb, M.; Freytes, D.O.; Hoffman, M.; Monroe, M.; Brown, A.C. Platelet-like particles improve fibrin network properties in a hemophilic model of provisional matrix structural defects. Journal of Colloid and Interface Science (2020).
-
Nandi, S.; Mohanty, K.; Nellenbach, K.; Sproul, E.P.; Erb, M.; Muller, M.; Brown, A.C. Ultrasound enhanced synthetic platelet therapy for enhanced wound repair. ACS Biomaterials Science & Engineering (2020).
-
Chee, E.; Nandi, S.; Nellenbach, K.; Mihalko, E.; Snider, D.; Morril, L.; Sproul, E.; Sollinger, J.; Cruse, G., Hoffman, M.; Brown, A.C. Nanosilver composite pNIPAm microgels for the development of antimicrobial platelet-like particles. Journal of Biomedical Materials Research: Part B – Applied Biomaterials (2020).
-
Nandi, S.; Sproul, E.P.; Nellenbach, K.; et al. Platelet-like Particles Dynamically Stiffen Fibrin Matrices and Improve Wound Healing Outcomes. Biomaterials Science (2019).
-
Sproul, E.P.; Nandi, S.; Chee, E.; Sivadanam, S.; Igo, B.J.; Schreck, L.; Brown, A.C. Development of biomimetic antimicrobial platelet-like particles comprised of microgel nanogold composites. Regenerative Engineering and Translational Medicine (2019).
-
Sproul, E.P.; Nandi, S.; Roosa, C.; Schreck, L.; Brown, A.C. Biomimetic Microgels with Controllable Deformability Improve Healing Outcomes. Advanced Biosystems (2018).
-
Brown, A.; Stabenfeldt, S.; Ahn, B. et al. Ultrasoft microgels displaying emergent platelet-like behaviours. Nature Materials (2014).